Local Factors Affecting Tumor Growth. I. Effect of Tissue Homogenates.

incidence of hepatic metastases is greatly aug mented by either direct hepatic trauma (3) or liver damage induced by a variety of other modalities such as alteration of hepatic blood flow (4), inter ference with reticuloendothelial function (7), or cirrhosis produced with carbon tetrachioride ,(8). In addition, growth of dormant tumor cells has been stimulated by hepatic injury (5). The precise mechanism(s) whereby such damage enhances tumor growth is not known. However, the possi biity has been considered that damaged or regen erating liver accelerated tumor growth through the elaboration of a humoral factor similar to that which has been noted (2, 18, 24) to influence liver